Provided are an apparatus and method for crystallizing a culture solution using a PCA process. The method for crystallizing a culture solution using a PCA process comprises the steps of: supplying, to a container, a culture solution including a first solvent and a target material dissolved in the first solvent； supplying a third solvent to the container； and supplying a second solvent to the container. The first to third solvents form a multi-component mixture, and the target material precipitates. The apparatus for crystallizing a culture solution using a PCA process is an apparatus for acquiring a target material by drying a culture solution including a first solvent and the target material being dissolved in the first solvent, the apparatus comprising: a high-pressure container to which the culture solution is supplied； a first supply unit which is connected to the high-pressure container and supplies a second solvent to the high-pressure container； a second supply unit which is connected to the high-pressure container and supplies a third solvent； a pre-cooler which is provided adjacent to the first supply unit and pre-cools the second solvent discharged from the first supply unit； and a pre-heater which is provided adjacent to the high-pressure container and pre-heats the second solvent supplied to the high-pressure container.L'invention concerne un appareil et une méthode de cristallisation d'une solution de culture à l'aide d'un traitement de PCA. La méthode de cristallisation d'une solution de culture à l'aide d'un traitement de PCA comprend les étapes consistant à : placer, dans un récipient, une solution de culture comprenant un premier solvant et une substance cible dissoute dans le premier solvant ； placer un troisième solvant dans le récipient ； et placer un deuxième solvant dans le récipient. Les premier à troisième solvants forment un mélange à constituants multiples, et la substance cible forme un précipité. L'appareil de cristallisation d'une soluti
