HETEROARYLENE-BRIDGED BENZODIAZEPINE DIMERS, CONJUGATES THEREOF, AND METHODS OF MAKING AND USING

• 收藏
• 分享

专利权人:

BRISTOL-MYERS SQUIBB COMPANY

发明人:

MCDONALD, Ivar, M.,CHOWDARI, Naidu, S.,JOHNSON, Walter, Lewis,ZHANG, Yong,BORZILLERI, Robert, M.,GANGWAR, Sanjeev

申请号：

SG11201705645Y

公开号：

SG11201705645YA

申请日:

2016.01.13

申请国别(地区):

SG

年份:

2017

代理人:

摘要：

Benzodiazepine dimers having a structure represented by wherein X comprises a heteroaromatic moiety and is as further defined in the application； R1 is and the other variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/