DANGELO Igor,BLEILE DUSTIN,TOM YEW Stacey A L,ESCOBAR CABRERA ERIC,LARIO PAULA I,OHRN ANDERS,POON DAVID K Y,DIXIT SURJIT B
申请号：
IN9182/DELNP/2012
公开号：
IN2012DN09182A
申请日:
2012.10.23
申请国别(地区):
IN
年份:
2014
代理人:
摘要：
Rationally designed antibodies and polypeptides that comprise multiple Fc region amino acid substitutions that synergistically provide enhanced selectivity and binding affinity to a target Fc receptor are provided. The polypeptides are mutated at multiple positions to make them more effective when incorporated in antibody therapeutics than those having wild type Fc components.
