Hongxian He;Stephen R. Fahnestock;Kristy N. Kostichka;Qiong Cheng;Hong Wang
发明人:
Qiong Cheng,Stephen R. Fahnestock,Hongxian He,Kristy N. Kostichka,Hong Wang
申请号：
US12632831
公开号：
US08697654B2
申请日:
2009.12.08
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Short single chain peptides having affinity for a target surface often lack the binding durability required for certain commercial applications. One way to improve durability is to promote multivalent binding by linking together binding sequences using peptide linkers. However, the resulting single chain binding peptides often suffer from linker entropy. It has been discovered that the use of rigid peptide linkers when linking together multiple binding sequences enhances the binding affinity of the resulting single chain peptide.
