DANGELO, IGOR,BLEILE, DUSTIN,TOM-YEW, STACEY A. L.,ESCOBAR-CABRERA, ERIC,LARIO, PAOLA, I.,OHRN, ANDERS,POON, DAVID K. Y.,DIXIT, SURJIT, B.
申请号：
EP11761857
公开号：
EP2552957A4
申请日:
2011.03.28
申请国别(地区):
EP
年份:
2013
代理人:
摘要：
Rationally designed antibodies and polypeptides that comprise multiple Fc region amino acid substitutions that synergistically provide enhanced selectivity and binding affinity to a target Fc receptor are provided. The polypeptides are mutated at multiple positions to make them more effective when incorporated in antibody therapeutics than those having wild-type Fc components.
