D'Angelo, Igor,Bleile, Dustin,Tom-Yew, Stacey A. L.,Escobar-Cabrera, Eric,Lario, Paola I.,Ohrn, Anders,Poon, David K. Y.,Dixit, Surijit B.,DAngelo, Igor
申请号：
AU2011235569
公开号：
AU2011235569B2
申请日:
2011.03.28
申请国别(地区):
AU
年份:
2016
代理人:
摘要：
Rationally designed antibodies and polypeptides that comprise multiple Fc region amino acid substitutions that synergistically provide enhanced selectivity and binding affinity to a target Fc receptor are provided. The polypeptides are mutated at multiple positions to make them more effective when incorporated in antibody therapeutics than those having wild-type Fc components.
