An infusate tubing clamp system for an infusion pump includes at least one movable tubing holder for removably securing a portion of infusate tubing. An actuator is operatively coupled to the at least one movable tubing holder. When the actuator is activated, the at least one movable tubing holder responsively and reversibly moves to a position that compressively clamps the portion of infusate tubing with sufficient force to temporarily and reversibly occlude the infusate tubing.
