An infusion line clamp system includes a clamp configured to attach to an infusion line and reversibly occlude the infusion line. The clamp is biased to occlude the infusion line except when acted upon by an externally applied opening force. The system also includes an infusion pump having a control system, a clamp receptacle configured to releasably secure the clamp to the infusion pump, and a clamp actuation mechanism that is configured to selectively actuate the clamp under command of the control system, by selective application of opening force to the clamp when the clamp is secured to the pump.
