The disclosure discloses a novel irrigation and aspiration system. A pump (6) is disposed on an irrigation tube (2) for delivering irrigation fluid. The irrigation tube (2) is connected in series with a check valve (3) and then connected with a first port of a tee joint (4); a second port of the tee joint (4) is connected with a suction tube of a negative pressure device through an aspiration tube (5); an electronic choke device (7) is installed on the aspiration tube (5); a third port of the tee joint is connected with an irrigation and aspiration common tube (8) which is also connected with a terminal execution device. Both the electronic choke device (7) and the pump (6) are controlled by a host computer. The electronic choke device (7) is turned off when the pump (6) works; and the pump (6) is stopped when the electronic choke device (7) is turned on. The novel irrigation and aspiration system is in combination with a variety of medical terminal execution devices using simple tubes to form a gastric lavage machine, and can be matched with a gastrointestinal endoscope without water delivery function or surgical operating instruments. The system is simple in structure, convenient to operate, easy to dismount, clean and disinfect, and also integrates irrigation and aspiration functions and will not readily be blocked during aspiration, so that the workload of medical staffs and the running cost are greatly decreased.