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THERAPEUTIC ANTIBODIES
专利权人:
НОВО НОРДИСК А/С (DK)
发明人:
ЗАН Стефан (DK),ЦЕУТЕН Луис Хьеррильд (DK),ХАНСЕН Анкер Йон (DK),КЬЯЭРГААРД Кристиан (DK),ЛУНД Сёрен (DK)
申请号:
RU2013155029/10
公开号:
RU2013155029A
申请日:
2012.06.04
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. An antibody that binds to C5aR, where the heavy chain variable region of the indicated antibody contains the sequences CDR1, CDR2 and CDR3, where the specified sequence of CDR1 includes SEQ ID 1, 9, 17 or 25, or any of the indicated sequences with 1, 2 or 3 amino acid substitutions , deletions or insertions, and / or where the specified sequence of CDR2 includes SEQ ID 2, 10, 18 or 26, or any of the indicated sequences with 1, 2 or 3 amino acid substitutions, deletions or insertions, and / or where the specified sequence of CDR3 includes SEQ ID 3, 11, 19 or 27 or any of these sequences with 1, 2 or 3 amino acid substitutions, deletions or insertions. 2. An antibody that binds to C5aR, where the variable region of the light chain of the indicated antibody contains the sequences CDR1, CDR2 and CDR3, where the specified sequence of CDR1 includes SEQ ID 5, 13, 21 or 29 or any of these sequences with 1, 2 or 3 amino acid substitutions, deletions or inserts, and / or where the specified sequence of CDR2 includes SEQ ID 6, 14, 22 or 30, or any of these sequences with 1, 2 or 3 amino acid substitutions, deletions or inserts, and / or where the specified sequence of CDR3 includes SEQ ID 7, 15, 23 or 31 or any of y sequences than those indicated with 1, 2 or 3 amino acid substitutions, deletions or vstavkami.3. The antibody according to any one of paragraphs. 1 or 2, which is selected among: a. antibodies in which the CDRs of the variable region of the heavy chain contain SEQ ID 1, 2 and 3 or the indicated sequences with 1 amino acid substitution, deletion and / or insertion, and where the CDRs of the variable light chain contain SEQ IDs 5, 6 and 7 or the indicated sequences with 1 amino acid substitution, deletion and / or insertion, b. a�1. Антитело, связывающееся с C5aR, где вариабельная область тяжелой цепи указанного антитела содержит последовательности CDR1, CDR2 и CDR3,где указанная последовательность CDR1 включает SEQ ID 1, 9, 17 или 25 или любую из указанных после
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