WATTS, RYAN,PFEIFER, ANDREA,MUHS, ANDREAS,PIHLGREN, MARIA
申请号：
NZ59949708
公开号：
NZ599497A
申请日:
2008.06.12
申请国别(地区):
NZ
年份:
2013
代理人:
摘要：
Patent No. 599497 Disclosed is a chimeric antibody or fragment thereof, or humanized antibody or fragment thereof, capable of specifically binding beta amyloid, wherein the chimeric antibody or fragment thereof, or the humanized antibody or fragment thereof, comprises (i) the amino acid sequence of GFTFSSYGMS representing CDR1, the amino acid sequence of SINSNGGSTYYPDSVK representing CDR2 and the amino acid sequence of GDY representing CDR3 of the Heavy Chain Variable Region (HCVR), and (ii) the amino acid sequence of RSSQSLVYSNGDTYLH representing CDR1, the amino acid sequence of KVSNRFS or the amino acid sequence of SEQ ID NO: 5 with one amino acid substitution representing CDR2, and the amino acid sequence of SQSTHVPWT representing CDR3 of the Light Chain Variable Region (LCVR), wherein the chimeric antibody or fragment thereof, or the humanized antibody or fragment thereof comprises an IgG1 Fc region comprising an amino acid substitution at any one or more of amino acid positions 238, 239, 248, 249, 252, 254, 268, 269, 270, 272, 278, 289, 292, 293, 294, 295, 296, 298, 301, 303, 322, 324, 327, 329, 333, 335, 338, 340, 373, 376, 382, 388, 389, 414, 416, 419, 434, 435, 437, 438 or 439 of the Fc region.
