FRENVIK, JANNE OLSEN,法兰维克 珍 欧森,法蘭維克 珍 歐森,RYAN, OLAV B.,莱恩 欧拉 B,萊恩 歐拉 B
申请号：
TW106100136
公开号：
TW201726178A
申请日:
2017.01.04
申请国别(地区):
TW
年份:
2017
代理人:
摘要：
The invention provides a method for the purification of complexed227Th from a mixture comprising complexed227Th and223Ra (complexed or in solution), said method comprising: i) preparing a first solution comprising a mixture of complexed227Th ions and223Ra ions in a first aqueous buffer ii) loading said first solution onto a separation material iii) eluting complexed227Th from said separation material whereby to generate a second solution comprising complexed227Th iv) Optionally rinsing said separation material using a first aqueous washing medium The invention additionally provides a purified227Th solution, a pharmaceutical product and its use in treatment of disease such as cancer and a kit for generation of such a product.本發明提供一種用於自包含錯合227Th及223Ra (經錯合或在溶液中)之混合物純化錯合227Th的方法,該方法包含: i) 製備包含錯合227Th離子與223Ra離子之混合物於第一水性緩衝液中的第一溶液; ii) 將該第一溶液裝載至分離材料上; iii) 自該分離材料溶離錯合227Th,由此產生包含錯合227Th的第二溶液; iv) 視情況使用第一水性洗滌介質沖洗該分離材料; 本發明另外提供一種經純化227Th溶液、一種醫藥產品及其在治療諸如癌症之疾病中之用途及一種用於產生此種產品的套組。
