The present invention provides a kind of methods for from the purifying mixture 227Th comprising 227Th and 223Ra, which comprises i) prepares the first solution, it includes the mixtures for the 227Th and 223Ra ions being dissolved in the first aqueous buffer Ii) first solution is loaded on separate substance such as strong cation-exchanging resin Iii 227Th) is eluted from the separate substance, thus generates the second solution comprising 227Th Iv) separate substance optionally is rinsed using the first Aqueous wash medium Invention additionally provides the method for being used to form radiopharmaceutical of 227Th including complexing purifying a kind of, the drug products and its purposes in treatment diseases such as cancer and the kits for generating such product.