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19-nor C3, 3-disubstituted C21-N-pyrazolyl steroids and methods of use thereof
专利权人:
SAGE THERAPEUTICS; INC.
发明人:
Gabriel Martinez Botella,Boyd L. Harrison,Albert Jean Robichaud,Francesco G. Salituro,Richard Thomas Beresis
申请号:
US14785171
公开号:
US09512165B2
申请日:
2014.04.17
申请国别(地区):
US
年份:
2016
代理人:
摘要:
Provided herein are 19-nor C3,3-disubstituted C21-pyrazolyl steroids of Formula (I), and pharmaceutically acceptable salts thereof; wherein, R1, R2, R3a, R3b, R4a, R4b, R5, R6, and R7 are as defined herein. Such compounds are contemplated useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, convulsive disorders, disorders of memory and/or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and/or withdrawal syndromes, and tinnitus.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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