PROBLEM TO BE SOLVED: To provide an enzymatic production method for a brain-function-improving peptide.SOLUTION: The method for producing a brain-function-improving peptide includes a step of hydrolyzing milk casein by an enzymatic catalyst including a protease to produce a hydrolysate including (i) a peptide comprising a specific amino acid sequence or a peptide comprising an amino acid sequence in which one or two amino acid residues are deleted, substituted or added in this amino acid sequence, (ii) a peptide comprising another specific amino acid sequence or a peptide comprising an amino acid sequence in which one or two amino acid residues are deleted, substituted or added in this amino acid sequence, or (iii) a mixture of the peptides of (i) and (ii). The generation yield of each of the peptides is at least 2% or the total generation yield of the mixture is at least 10%. A food product, drink, or medicinal composition including the hydrolysate is also provided.COPYRIGHT: (C)2015,JPO&INPIT【課題】脳機能改善用ペプチドの酵素的製造方法を提供する。【解決手段】乳カゼインをプロテアーゼを含む酵素触媒で加水分解して、(i)特定のアミノ酸配列からなるペプチド又はそのアミノ酸配列において1若しくは2個のアミノ酸残基の欠失、置換又は付加を含むアミノ酸配列からなるペプチド、(ii)他の特定のアミノ酸配列からなるペプチド又はそのアミノ酸配列において1若しくは2個のアミノ酸残基の欠失、置換又は付加を含むアミノ酸配列からなるペプチド、或いは(iii)前記(i)及び(ii)のペプチドの混合物を含む加水分解産物を生成することを含む、但し、該ペプチドの各々の生成収率が2%以上である、又は該混合物の合計生成収率が10%以上であることを特徴とする、脳機能改善用ペプチドの製造方法、ならびに該加水分解産物を含む飲食品又は医薬組成物。【選択図】図1
