PROBLEM TO BE SOLVED: To provide novel means which can contribute to application of immunotherapy for leukemia treatment, and to provide a screening method thereof.SOLUTION: The invention is an isolated peptide consisting of an amino acid sequence in which (i) an amino acid sequence of sequence ID number 1, or (ii) a second amino acid of the sequence ID number 1 is substituted by any of Y, W, or M, and/or a ninth amino acid is substituted by any of F, L, or W. And the invention is also a dendritic cell which is pulsed with (i) the above peptide, or (ii) a protein consisting of an amino acid sequence having 90% or more of homology to a sequence ID number 2.COPYRIGHT: (C)2015,JPO&INPIT【課題】免疫療法の白血病治療への適用に寄与し得る新規な手段及びそのスクリーニング方法の提供。【解決手段】本発明は、(i)配列番号1のアミノ酸配列、もしくは(ii)配列番号1の2番目アミノ酸がY、W、Mのいずれかに置換され且つ/又は9番目のアミノ酸がF、L、Wのいずれかに置換されたアミノ酸配列、からなる単離されたペプチドである。また、本発明は、(i)上記のペプチド、又は(ii)配列番号2と90%以上の相同性を有するアミノ酸配列からなるタンパク質、でパルスされた樹状細胞でもある。【選択図】図9
