A tissue and/or cell sampling device for biopsies having a catheter sized for translation through a lumen on an instrument such as a bronchoscope. An aspiration needle engaged to a control member is employable by translation to remove a core of tissue from a sampling location. The translation can be limited to maintain the needle retracted into an axial passage. Forceps or a brush are translatably engaged within the axial core of the needle and are translatable from the tip of the needle to take tissue and/or cell samples. The device is employable to allow for use of either sampling device independently, or sequently, to allow deep tissue and/or cell samples to be retrieved from the distal end of the core tissue sample retrieved by the needle.
