A tissue and/or cell sampling device for biopsies having a catheter sized for translation through a lumen on an instrument such as a bronchoscope. An aspiration needle engaged to a control member through the catheter is controllable to remove a core of tissue from a sampling location. Forceps or a brush are translatably engaged within the axial core of the needle and are translatable from the tip of the needle to take tissue and/or cell samples. The device is employable to allow the surgeon to use either sampling device independently, or sequently to allow deep tissue and/or cell samples to be retrieved from the distal end of the core tissue sample retrieved by the needle.
