Diabetic nephropathy is one of the complications of diabetes mellitus and is known for kidney complications. During diabetic nephropathy, the functional unit of kidney is damaged leading to increased filtration rate. Diet plays a major role in the management of diabetes and its associated complications. In this aspect, dietary antioxidants are playing an important role. Quercetin is a well- documented bioflavonoid occurring in many foods and is known to be present in higher concentrations in onions, apples, broccoli, green tea and red wine. A formulation involving quercetin was examined for its efficacy on diabetic nephropathy state. The experimental groups showed considerable improvement in ameliorating the diabetic status as assessed by urine sugar, urine volume and fasting blood sugar. The kidney damage was estimated by measuring the glomerular filtration rate in diabetic and treated rats. The quercetin fed diabetic rats showed about 50% improvement in the diabetic nephropathy state.
