The present invention provides: a microbubble-melanin nanoparticle-peptide complex comprising a microbubble, a melanin nanoparticle attached to the surface of the microbubble, in which a paramagnetic metal ion is bonded thereto, and a targeting peptide bound to the nanoparticle； and a method for manufacturing the same. The microbubble-melanin nanoparticle-peptide complex of the present invention has an excellent targeting effect by comprising a peptide capable of selectively targeting a specific protein expressed in a specific cancer.본 발명은 마이크로버블, 상기 마이크로버블의 표면에 부착되고 상자성 금속 이온이 결합된 멜라닌 나노입자 및 상기 나노입자에 결합된 타겟팅 펩타이드를 포함하는 마이크로버블-멜라닌 나노입자- 펩타이드 복합체, 및 이의 제조방법을 제공한다.
