NEW POLYMORPHE FORMS OF 6- (1-METHYL-1H-PYRAZOL-4-YL) -2- {3- [5- (2-MORPHOLIN-4-YL-ETHOXY) -PYRIMIDIN-2-YL] -BENZYL} - 2H-PYRIDAZINE-3-ON DIHYDROGEN PHOSPHATE AND PROCEDURES FOR PREPARING THEREOF
DONINI, CRISTINA,KRIEGBAUM, EVA,KUEHN, CLEMENS,BECKER, AXEL,SAAL, CHRISTOPH,SCHADT, OLIVER,DORSCH, DIETER,STIEBER, FRANK
申请号：
DK09756445
公开号：
DK2361250T3
申请日:
2009.11.24
申请国别(地区):
DK
年份:
2013
代理人:
摘要：
The present invention relates to 6-(1-methyl-1H-pyrazol-4-yl)-2-{3-[5-(2-morpholin-4-yl-ethoxy)-pyrimidin-2-yl]-benzyl}-2H-pyridazin-3-one dihydrogenphosphate, its solvates and crystalline modifications thereof. The present invention further relates to processes of manufacturing these crystalline modifications as well as their use in the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by the inhibition, regulation and/or modulation of signal transduction of kinases, in particular by the inhibition of tyrosine kinases, e.g. pathophysiological conditions such as cancer.
