צורות פולימורפיות של 6–(1–מתיל–h1–פירזול–4–yl)–2–{3–[5–(2–מורפולין–4–yl–אטוקסי)–פירמידין–2–yl]בנזיל}–h2–פרידזין–3–דיהידרוגנפוספט אחד ותהליך לייצורם

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专利权人:

MERCK PATENT GMBH

发明人:

申请号：

IL21364711

公开号：

IL213647A

申请日:

2011.06.19

申请国别(地区):

IL

年份:

2013

代理人:

摘要：

The present invention relates to 6-(1-methyl-1H-pyrazol-4-yl)-2-{3-[5-(2-morpholin-4-yl-ethoxy)-pyrimidin-2-yl]-benzyl}-2H-pyridazin-3-one dihydrogenphosphate, its solvates and crystalline modifications thereof. The present invention further relates to processes of manufacturing these crystalline modifications as well as their use in the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by the inhibition, regulation and/or modulation of signal transduction of kinases, in particular by the inhibition of tyrosine kinases, e.g. pathophysiological conditions such as cancer.

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中国工程科技知识中心

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