Polymorphic forms of 6-(1-methyl-1H-pyrazol-4-yl)-2-{3-[5-(2-morpholin-4-yl-ethoxy)-pyrimidin-2-yl]-benzyl}-2H-pyridazin-3-one dihydrogenphosphate and processes of manufacturing thereof
Christoph Saal;Clemens Kuehn;Axel Becker;Frank Stieber;Dieter Dorsch;Eva Kriegbaum;Cristina Donini;Oliver Schadt
发明人:
Axel Becker,Clemens Kuehn,Christoph Saal,Oliver Schadt,Dieter Dorsch,Eva Kriegbaum,Frank Stieber,Cristina Donini
申请号：
US13141142
公开号：
US08586599B2
申请日:
2009.11.24
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention relates to 6-(1-methyl-1H-pyrazol-4-yl)-2-{3-[5-(2-morpholin-4-yl-ethoxy)-pyrimidin-2-yl]-benzyl}-2H-pyridazin-3-one dihydrogenphosphate, its solvates and crystalline modifications thereof. The present invention further relates to processes of manufacturing these crystalline modifications as well as their use in the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by the inhibition, regulation and/or modulation of signal transduction of kinases, in particular by the inhibition of tyrosine kinases, e.g. pathophysiological conditions such as cancer.
