polymorphic forms of 6- (1-methyl-1h-pyrazol-4-yl) -2- {3- [5- (2-morpholin-4-yl-ethoxy) -pyrimidin-2-yl] -dihydrogen phosphate benzyl} -2h-pyridazin-3-one and their manufacturing processes
AXEL BECKER,CHRISTOPH SAAL,CLEMENS KUEHN,CRISTINA DONINI,DIETER DORSCH,EVA KRIEGBAUM,FRANK STIEBER,OLIVER SCHADT
申请号：
BRPI0923480
公开号：
BRPI0923480A2
申请日:
2009.11.24
申请国别(地区):
BR
年份:
2016
代理人:
摘要：
The present invention relates to 6-(1-methyl-1H-pyrazol-4-yl)-2-{3-[5-(2-morpholin-4-yl-ethoxy)-pyrimidin-2-yl]-benzyl}-2H-pyridazin-3-one dihydrogenphosphate, its solvates and crystalline modifications thereof. The present invention further relates to processes of manufacturing these crystalline modifications as well as their use in the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by the inhibition, regulation and/or modulation of signal transduction of kinases, in particular by the inhibition of tyrosine kinases, e.g. pathophysiological conditions such as cancer.
