AQUINO CHRISTOPHER JOSEPH,COLLINS JON LOREN,COWAN DAVID JOHN,WU YULIN
申请号：
NZ60275411
公开号：
NZ602754A
申请日:
2011.04.27
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
602754 Provided are dioxido-phenyl-benzothiazepin derivatives of formula (I), where Q, R1, R2, R3, R4 and X are as defined in the specification. An example of the derivatives is 3-({ [(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]carbonyl} amino)-2,2-dimethylpropanoic acid. Methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and therapeutic uses of them are further provided. These compounds are suitable for treating metabolic disorders, particularly diabetes mellitus (Type I and Type II) or obesity.
