Dunn, Steven Mark,Li, Yi,Jakobsen, Bent Karsten,Molloy, Peter Eamon
申请号：
AU2013202288
公开号：
AU2013202288A1
申请日:
2013.04.02
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
#$%^&*AU2013202288A120130502.pdf#####C:WRPortbrDCC\AM 4527388.l.DOC-9/0/2012 ABSTRACT The present invention provides TCRs having an affinity (KD) of less than or equal to IpM, and/or an off-rate (koff) of 1x10 3 S~1 or slower, for the SLYNTVATL-HLA- A* 0201 complex provided that when the said TCR is presented by cell and comprises SEQ ID NOs: 1 and 2, the cell is not a native T cell. Such TCRs are useful, either alone or associated with a therapeutic agent, for targeting HIV infected cells presenting that complex.
