Dunn, Steven Mark,Li, Yi,Jakobsen, Bent Karsten,Molloy, Peter Eamon
申请号：
AU2012211503
公开号：
AU2012211503B2
申请日:
2012.08.10
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
#$%^&*AU2012211503B220140130.pdf#####C \NRPonblDCC\AMT\45273H8 I.DOC-9M812012 ABSTRACT The present invention provides TCRs having an affinity (KD) of less than or equal to 1pM, and/or an off-rate (kog-) of 1x10~3 S- or slower, for the SLYNTVATL-HLA- A* 0201 complex provided that when the said TCR is presented by cell and comprises SEQ ID NOs: 1 and 2, the cell is not a native T cell. Such TCRs are useful, either alone or associated with a therapeutic agent, for targeting HIV infected cells presenting that complex.
