Neutralisation des anticorps monoclonaux contre le récepteur Nogo 66 (NGR) et utilisations associées

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专利权人:

Abbott Laboratories

发明人:

申请号：

EP13184160.3

公开号：

EP2700410A1

申请日:

2007.11.21

申请国别(地区):

EP

年份:

2014

代理人:

摘要：

The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind to the Nogo-66 receptor. Specifically, these antibodies have the ability to inhibit the binding of the natural ligand of the Nogo-66 receptor and neutralize the Nogo-66 receptor. These antibodies or portions thereof of the invention are useful for detecting NgR and for inhibiting NgR activity, for example in a human suffering from a disorder in which NgR or Nogo-66 activity is detrimental.

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