MEZLER, MARIO,MOELLER, ACHIM,MUELLER, REINHOLD,MUELLER, BERNHARD K.,GHAYUR, TARIQ,BARLOW, EVE H.,SCHMIDT, MARTIN,MEYER, AXEL,TEUSCH, NICOLE
申请号：
CA2670368
公开号：
CA2670368C
申请日:
2007.11.21
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind to the Nogo-66 receptor. Specifically, these antibodies have the ability to inhibit the binding of the natural ligand of the Nogo-66 receptor and neutralize the Nogo-66 receptor. These antibodies or portions thereof of the invention are useful for detecting NgR and for inhibiting NgR activity, for example in a human suffering from a disorder in which NgR or Nogo-66 activity is detrimental.
