Mario Mezler,Achim Moeller,Reinhold Mueller,Bernhard K. Mueller,Tariq Ghayur,Eve H. Barlow,Martin Schmidt,Axel Meyer,Nicole Teusch
申请号：
US14989532
公开号：
US10040852B2
申请日:
2016.01.06
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind to the Nogo-66 receptor. Specifically, these antibodies have the ability to inhibit the binding of the natural ligand of the Nogo-66 receptor and neutralize the Nogo-66 receptor. These antibodies or portions thereof of the invention are useful for detecting NgR and for inhibiting NgR activity, for example in a human suffering from a disorder in which NgR or Nogo-66 activity is detrimental.
