Mario Mezler,Achim Moeller,Reinhold Mueller,Bernhard K. Mueller,Tariq Ghayur,Eve H. Barlow,Martin Schmidt,Axel Meyer,Nicole Teusch
申请号：
US16055659
公开号：
US20190233510A1
申请日:
2018.08.06
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind to the Nogo-66 receptor. Specifically, these antibodies have the ability to inhibit the binding of the natural ligand of the Nogo-66 receptor and neutralize the Nogo-66 receptor. These antibodies or portions thereof of the invention are useful for detecting NgR and for inhibiting NgR activity, for example in a human suffering from a disorder in which NgR or Nogo-66 activity is detrimental.
