A method of preparing a biological composite matrix system includes combining tissue microparticles with a curable medium. The tissue microparticles are formed by pulverizing tissue, sorting the pulverized tissue particles, and decellularizing the pulverized tissue particles. The tissue microparticles are then mixed with the curable medium and the resulting composite is cured to form a microparticle-medium composite matrix. The microparticle-medium composite matrix is compressed to increase the strength of the matrix and to increase the density of the microparticles to a predetermined density.
