Immunomodulatory polypeptides derived from il- 2 and their use thereof in the therapeutic of cancer and chronic infections

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专利权人:

CENTRO DE INMUNOLOGIA MOLECULAR (CIM)

发明人:

MARQUEZ PERERA GABRIEL,LAGE DAVILA AGUSTIN BIENVENIDO,GARCIA MATINEZ KARINA,CARMENATE PORTILLA TANIA,GONZALEZ ROCHE DIAMILE,PEREZ RODRIGUEZ SAUMEL,LEON MONZON KALET

申请号：

NZ59979210

公开号：

NZ599792A

申请日:

2010.11.26

申请国别(地区):

NZ

年份:

2014

代理人:

摘要：

599792 Disclosed is an immunomodulatory polypeptide derived from IL-2, which comprises point mutations in respect to the sequence of human IL-2, wherein the polypeptide is selected from the group consisting of (i) said polypeptide comprising mutations Q22V, Q126A, and S130G I129D； (ii) said polypeptide comprising mutations L18N, Q126Y and S130R； (iii) said polypeptide comprising mutations Q13Y, Q126Y, I129D and S130R； and (iv) said polypeptide comprising mutations L18N, Q22V, T123A, and S130R I129D.

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