Shawn P. Iadonato,Charles L. Magness,Gary Rosenberg,Christina A. Scherer,Thierry Guillaudeux
申请号：
US13903926
公开号：
US09090947B2
申请日:
2013.05.28
申请国别(地区):
US
年份:
2015
代理人:
摘要：
A method for detecting a mutation related to the gene encoding OAS1. This and other disclosed mutations correlate with resistance of humans to viral infection including hepatitis C. Also provided is a therapeutic agent consisting of a protein or polypeptide encoded by the mutated gene, or a polynucleotide encoding the protein or polypeptide. Inhibitors of human OAS1, including antisense oligonucleotides, methods, and compositions specific for human OAS1, are also provided.
