Use of a virion of a respiratory syncytial virus with a mutation in the gene encoding for the g attachment protein for the prevention or treatment of a pneumoviral infection
DE STAAT DER NEDERLANDEN VERTEGENWOORDIGD DOOR DEMINISTER VAN VOLKSGEZONDHEID WELZIJN EN SPORT
发明人:
WILLEM LUYTJES,MYRA NOORELY WIDJOJOATMODJO
申请号：
IL17650006
公开号：
IL176500A
申请日:
2006.06.22
申请国别(地区):
IL
年份:
2015
代理人:
摘要：
The present invention relates to pneumoviral virions comprising a viral genome that has a mutation in a gene coding for a protein that is essential for infectivity of the pneumovirus, whereby the mutation causes a virus produced from only the viral genome to lack infectivity, and whereby the virion comprises the protein in a form and in an amount that is required for infectivity of the virion. The invention for relates to methods for producing the pneumoviral virions and for using the virions in the treatment or prevention of pneumoviral infection and disease. A preferred pneumoviral virion is a virion of Respiratory Syncytial Virus in which preferably the gene for the G attachment protein is inactivated and complemented in trans.
