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MEDICINAL FORMS OF IRON (III) CITRATE
专利权人:
КЕРИКС БАЙОФАРМАСЬЮТИКАЛЗ; ИНК. (US)
发明人:
ЛИ Генри Тронг (US)
申请号:
RU2012106139/15
公开号:
RU2012106139A
申请日:
2010.07.21
申请国别(地区):
RU
年份:
2013
代理人:
摘要:
1. A tablet containing 65-92 wt.% Iron (III) citrate and 4.5-30 wt.% A binder, while the ratio of the average surface area to the weight of the indicated tablet is 1 mn gram or more of this value, and% of water in tablet, determined by measuring the loss during drying, is less than 15 wt./wt.%. 2. A tablet according to claim 1, wherein the ratio of the average surface area to the weight of the tablet is 5 mn grams or more. A tablet according to claim 1, wherein the ratio of the average surface area to the weight of the tablet is 10 mn grams or more. The tablet according to claim 1, which contains at least 70 wt.% Iron (III) citrate. The tablet according to claim 1, which contains at least 80 wt.% Iron (III) citrate. 6. The tablet according to claim 1, which contains at least 90 wt.% Iron (III) citrate. The tablet of claim 1, wherein the binder consists of one or more of hydroxypropyl cellulose (HPC), hydroxypropyl methyl cellulose (HPMC), sodium alginate, alginic acid, guar gum, gum arabic, xanthan gum, carbopol, gum cellulose (carboxymethyl cellulose), ethyl maltodextrin, PVP / VA, povidone, microcrystalline cellulose, starch (partially or fully pregelatinized starch) and methyl cellulose. 8. The tablet according to claim 1, in which the% of water, determined by measuring the loss during drying, is less than 15 wt./wt. 9. The tablet according to claim 1, in which the% of water, determined by measuring the loss during drying, is less than 10 wt./wt. 10. The tablet according to claim 1, which further comprises a disintegrant selected from one or more of microcrystalline cellulose, croscarmellose sodium, crospovidone, �1. Таблетка, содержащая 65-92 мас.% цитрата железа (III) и 4,5-30 мас.% связующего, при этом отношение средней площади поверхности к массе указанной таблетки равно 1 мна грамм или больше этого значения, а % воды в таблетке, определяемый при измерении потерь при сушке, составляет меньше чем 15 мас./мас.%.2. Таблетка по п.1, в которой отношение средней пл
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