PROBLEM TO BE SOLVED: To provide an oxygen enriched preparation for eyes, which can be safely and easily manufactured and maintain a dissolved oxygen concentration in the preparation over a long period of time, and to provide a method of manufacturing the same.SOLUTION: The method of manufacturing the oxygen enriched preparation for eyes includes: (1) a step of injecting and sealing an oxygen non-replaced preparation for eyes in an oxygen permeable resin container and (2) a step of surrounding the oxygen permeable resin container in which the preparation for eyes is housed by the previous step by an oxygen impermeable or poorly permeable resin package, replacing oxygen inside a space formed between the resin container and the resin package so as to turn an oxygen concentration inside the space to 30-60 (v/v)%, and sealing the package.COPYRIGHT: (C)2013,JPO&INPIT【課題】安全且つ簡易に製造することができ、製剤中の溶存酸素濃度を長期間維持することのできる酸素富化眼用製剤、及びその製造方法を提供する。【解決手段】(1)酸素未置換の眼用製剤を酸素透過性樹脂容器内に注入・密封する工程と、(2)前記工程によって眼用製剤が収容された酸素透過性樹脂容器を、酸素不透過性又は低透過性樹脂包装体により包囲し、該樹脂容器と該樹脂包装体との間に形成される空間内の酸素濃度が30~60(v/v)%となるように該空間内へと酸素を置換し、該包装体を密封する工程とを備える。【選択図】なし
