UNIT DOSES FOR IMMEDIATE RELEASE OF GHB OR OF ONE OF THE THERAPEUTICALLY ACCEPTABLE SALTS THEREOF, ADMINISTERED ORALLY, AND THE USE THEREOF TO MAINTAIN ALCOHOL ABSTINENCE.
UNIT DOSES FOR IMMEDIATE RELEASE OF GHB OR OF ONE OF THE THERAPEUTICALLY ACCEPTABLE SALTS THEREOF, ADMINISTERED ORALLY, AND THE USE THEREOF TO MAINTAIN ALCOHOL ABSTINENCE 5 The present invention concerns immediate release, unit doses of GHB or one of the therapeutically acceptable salts thereof administered via oral route. Such unit doses contain between 0.37 and 1.75 g of GHB, more particularly as 10 sodium oxybate when under the form of granules, these granules have the following composition (weight % relative to the total weight of the granule): - Active ingredient (sodium oxybate): 50 to 60 % - Effervescent agent: 5 to 15 % - Diluent: 2 to 18 % 15 - Binder: 3 to 10 % - Substrate (Solid core of the granule): 15 to 25 % - Coating agent/ flavouring agent / sweetening agent / lubricant: 3 to 6 %. Application for maintaining abstinence from alcohol of patients with mild or moderate alcohol dependence or with severe or very severe alcohol dependence, either 20 suffering or not from liver disease. [No Suitable figure]
