Unit doses for immediate release of ghb or of one of the therapeutically acceptable salts thereof, administered orally, and the use thereof to maintain alcohol abstinence.
The present invention relates to unit doses for immediate release of GHB or of one of the therapeutically acceptable salts thereof, administered orally. These doses contain from 0.37 to 1.75 g of GHB, and more particularly sodium oxybate when they are present in the form of granules, the latter have the following composition (% relative to the total weight of the granule): - active principle (sodium oxybate): 50 to 60% - effervescent agent: 5 to 15% - diluent: 2 to 18% - binder: 3 to 10% - support (solid core of the granule): 15 to 25% - coating agent/flavouring agent/sweetening agent/lubricant: 3 to 6%. Application in the maintenance of alcohol abstinence for patients having a low, moderate, high or very high blood alcohol level, with or without liver failure.
