AM ENDE, Christopher William,GREEN, Michael Eric,JOHNSON, Douglas Scott,KAUFFMAN, Gregory Wayne,O'DONNELL, Christopher John,PATEL, Nandini Chaturbhai,PETTERSSON, Martin Youngjin,STEPAN, Antonia Friede,ODONNELL, Christopher John,STEPAN, Antonia Frieder
申请号：
ES13792085
公开号：
ES2609987T3
申请日:
2013.09.06
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound having the structure of Formula I, or a pharmaceutically acceptable salt thereof: ** Formula ** in which: X is a 5- to 14-membered heteroaryl containing 1-3 heteroatoms； R1 is hydrogen, halogen, C1-C6 alkyl, C3-C6 cycloalkyl or C2-C6 alkenyl； wherein said alkyl, cycloalkyl or alkenyl is optionally substituted with one to three substituents which are each independently selected from the group consisting of fluorine, hydroxyl and C1-C6 alkoxy； A is a C3-C6 cycloalkyl or a 4-10 membered heterocycloalkyl； wherein said cycloalkyl or heterocycloalkyl is optionally substituted with one to three substituents that are each independently selected from the group consisting of halogen and C1-C6 alkyl； R2a and R2b for each occurrence is independently hydrogen, fluorine, cyano, -CF3, C1-C6 alkyl, C2-C6 alkenyl, C3-C6 cycloalkyl, C4-C8 cycloalkyl, C2-C6 alkynyl or phenyl； wherein said alkyl, alkenyl, cycloalkyl, bicycloalkyl, alkynyl or phenyl is optionally substituted with one to three substituents that are each independently selected from the group consisting of cyano, C1-C3 alkyl and fluorine； or R2a and R2b, together with the carbon to which they are attached, form a 3 to 5 membered cycloalkyl optionally substituted with one to three of R8； R3 is hydrogen, halogen, C1-C6 alkyl, C2-C6 alkenyl, - (C (R10) 2) t- (C3-C6 cycloalkyl), - (C (R10) 2) t- (4-10 membered heterocycloalkyl ), - (C (R10) 2) t- (C6-C10 aryl), - (C (R10) 2) t- (5-10 membered heteroaryl) or - (C (R10) 2) t-OR12； wherein said alkyl, alkenyl, cycloalkyl, heterocycloalkyl, aryl or heteroaryl is optionally substituted with one to five of R11； R4a and R4b are each, independently hydrogen, -CF3 or C1-C6 alkyl, wherein said alkyl is optionally substituted with one to three substituents that are each independently selected from the group consisting of -CF3, cyano and fluorine； or R4a and R4b, together with the carbon to which they are attached, form a 3 to 5 membered cycloalkyl, wherein said cycloalkyl is o
