FIELD: chemistry.SUBSTANCE: invention relates to a novel derivative of 4-substituted-2- (N- (5-substituted-allylamide) phenyl) -amino) pyrimidine represented by formula (I). In formula (I)ring A is selected from a group consisting ofwhere Q is a bond； R is selected from a group consisting of hydrogen； X1, X2 and X3 each is independently selected from a group consisting of NR7 and CR8, where one or two of X1, X2 and X3 are NR7, wherein, when X2 is NR7, other groups are CR8, and a ring with said group X2 is joined by a carbon atom to a pyrimidine ring, or when two of X1, X2 and X3 are NR7, ring is joined by nitrogen atom of said group to pyrimidine ring； R1 is selected from the group consisting of:wherein three R6 in are optionally identical or different substitutes； R2 is selected from a group consisting of C1-8 alkyl, where C1-8 alkyl is optionally substituted with one or more groups selected from a group consisting of halogen； R3 is selected from a group consisting of hydrogen, halogen, trifluoromethyl, trifluoromethoxy and P(O)R11R12, where R11R12 are C1-6 alkyl； R4 are independently selected from a group consisting of hydrogen, halogen, cyano, C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, C3-8 cycloalkyl, 4-membered saturated heterocyclyl containing an oxygen atom in the cycle, -P(O)R11R12, where R11R12 are represented by C1-6 alkyl, -S(O)rR9, -OR10, -C(O)R10, where C1-8 alkyl is optionally substituted with one or more groups selected from a group consisting of halogen, hydroxy and -OR10； R6 is selected from a group consisting of hydrogen and C1-8 alkyl； R7 is selected from a group consisting of C1-8 alkyl, C2-8 alkenyl, C3-6 cycloalkyl, -S(O)rR9, -OR10, -C(O)R10 and 4-member saturated heterocyclyl containing an oxygen atom in a cycle； where C1-8 alkyl is substituted with one or more groups selected from a group consisting of hydroxy, C2-8 alkenyl and C2-8 alkynyl； R8 is selected from a group consisting of hydrogen, C1-8 alkyl, C3-8 cycloalkyl and -OR10； R9 is selecte
