АЛАВИ Фадил Ал (NZ),БОРК Олаф (NZ),ДЖАИН Рохит (NZ),НАНЬЯН Картигеян (NZ),ТАКЕР Иан Джордж (NZ)
申请号：
RU2015105251
公开号：
RU2015105251A
申请日:
2013.07.16
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. A ready-to-use composition for intramuscular and subcutaneous injection, including penetetamate (PNT) or its pharmaceutical equivalent, at least one oily carrier； anti-sintering substance. 2. The composition of claim 1, wherein the sintering agent comprises an emulsifier or dispersing agent. The composition of claim 2, wherein the sintering agent comprises a surfactant. The composition of claim 3, wherein the surfactant is selected from a compound with a hydrophobic lipophilic balance (HLB) from 7 to 16.5. The composition of claim 4, wherein the surfactant is polysorbate 80.6. The composition of claim 2, wherein the emulsifier or dispersant is a lipid-insoluble lecithin. The composition of claim 6, wherein the lipid-insoluble lecithin is phospholipon H90.8. The composition of claim 1, wherein the sintering agent comprises triacetin. The composition of claim 1, wherein the sintering agent is not a thickener. The composition according to claim 1, wherein the viscosity of the composition is below 3000 mPa · s at a temperature of 20 ° C and a shear rate of 1 / s is measured by the method of a bowl-shaped cylinder. The composition of claim 1, wherein the penetamate (PNT) or its pharmaceutical equivalent is 55% w / v. composition or less. 12. The composition of claim 11, wherein the concentration of penetamate (PNT) is from 15 to 55% w / v. The composition of claim 12, wherein the concentration of penetamate (PNT) in the composition is from 20 to 35% w / v. The composition of claim 1, wherein the oil carrier has a low viscosity. The composition of claim 1, wherein the composition is in liquid form. The composition of claim 1, wherein the particle diameter of dpenetamate (PNT) is from 8 to 30 microns. The composition of claim 1, which comprises a preservative. 18. The composition of claim 17, wherein1. Готовая к использованию композиция для внутримышечной и подкожной инъекции,включающая пенетамат (PNT) или его фармацевтический эквивалент；по меньшей мере, один масляный н
