CHEN, CHIN CHU,陈劲初,陳勁初,HSU, SHENG CHIEH,许胜杰,許勝傑,CHEN, YEN PO,陈彦博,陳彥博,LIN, TING WEI,林定威,林定威
申请号：
TW103142284
公开号：
TW201620535A
申请日:
2014.12.05
申请国别(地区):
TW
年份:
2016
代理人:
摘要：
The present invention relates to an Antrodia camphorata mycelium active substance for protecting nerve cells and a food composition thereof, wherein the Antrodia camphorata mycelium active substance is capable of inhibiting cytotoxicity caused by 10 M amyloid (Amyloid (25-35)), and also inhibiting cell apoptosis arising from mitochondrial rupture caused by 1-methyl-4-phenylpyridine (MPP+) at a non-cytotoxic concentration of 50 M. Therefore, the Antrodia camphorata mycelium active substance of this invention has a potential to prevent neurodegenerative diseases.本發明係關於一種保護神經細胞之樟芝菌絲體活性物質及其食品組合物;其中該樟芝菌絲體活性物質在50μM之無細胞毒性濃度下,可抑制由10μM澱粉樣蛋白(Amyloid β(25-35))引起的細胞毒性,亦能夠抑制1-甲基-4-苯基吡啶(MPP+)造成的粒線體斷裂所引起的細胞凋亡;因此本發明之樟芝菌絲體活性物質具有預防神經退化疾病的潛力。
