Pukyong National University Industry-University Cooperation Foundation
发明人:
Gun-Do KIM,Gyun-Pyung SHIN,Woo-Suk CHOI,Sang-Yeol LEE,Woe-Yeon KIM,Nam-Gyu PARK
申请号：
US13929523
公开号：
US20140100286A1
申请日:
2013.06.27
申请国别(地区):
US
年份:
2014
代理人:
摘要：
There is provided a composition including a veratric acid for preventing or treating inflammatory diseases. The veratric acid of the present invention has an excellent effect of inhibiting production of nitric oxide, an excellent activity of inhibiting production of IL-1β as a pro-inflammatory cytokine, and an excellent effect of inhibiting phosphorylation of MAPK, NF-κB, GSK-3β, and c-Raf in a macrophage cell stimulated by a stimulation factor that causes an inflammatory reaction. Thus, it can be used for development of medicines for treating inflammatory diseases which can be caused by excessive inflammatory reactions. Further, the veratric acid of the present invention does not induce toxicity to cells and is stable in the body. Thus, it can be used as a material of a health functional food capable of preventing or improving inflammatory diseases.
