ERIC ESCOBAR-CABRERA,GORDON YIU KON NG,GRANT RAYMOND WICKMAN,MARIO SANCHES,NINA E. WEISSER,SURJIT BHIMARAO DIXIT
申请号：
BR112016012157
公开号：
BR112016012157A2
申请日:
2014.11.27
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
Provided herein are biparatopic antigen-binding constructs that specifically bind HER2. The biparatopic antigen-binding constructs comprise one antigen-binding moiety that binds to ECD2 of HER2, a second antigen-binding moiety that binds to ECD4 of HER2, and an Fc. At least one of the antigen-binding moieties is an scFv. The biparatopic antigen-binding constructs can be used in the treatment of cancer.
