Gordon Yiu Kon Ng,Nina E. Weisser,Grant Raymond Wickman
申请号：
US15036175
公开号：
US20160297891A1
申请日:
2014.11.13
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Provided herein are methods of use and treatment using a first or a first and second monovalent antigen-binding constructs targeting HER2. The monovalent antigen-binding constructs can include at least one antigen-binding polypeptide comprising a heavy chain variable domain, wherein the antigen-bind polypeptide specifically binds HER2； and a heterodimeric Fc, the Fc comprising at least two CH3 sequences, wherein the Fc is coupled, with or without a linker, to the antigen-binding polypeptide.
