WEISSER, NINA E.,NG, GORDON YIU KON,WICKMAN, GRANT RAYMOND,DIXIT, SURJIT BHIMARAO,ESCOBAR-CABRERA, ERIC,SANCHES, MARIO
申请号：
CA2931356
公开号：
CA2931356A1
申请日:
2014.11.27
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
Provided herein are biparatopic antigen-binding constructs that specifically bind HER2. The biparatopic antigen-binding constructs comprise one antigen-binding moiety that binds to ECD2 of HER2, a second antigen-binding moiety that binds to ECD4 of HER2, and an Fc. At least one of the antigen-binding moieties is an scFv. The biparatopic antigen-binding constructs can be used in the treatment of cancer.
