OOST THORSTEN,ANDERSKEWITZ RALF,HAMPRECHT DIETER WOLFGANG,HOENKE CHRISTOPH,MARTYRES DOMNIC,RIST WOLFGANG,SEITHER PETER
申请号：
NZ60063711
公开号：
NZ600637A
申请日:
2011.01.24
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
The disclosure relates to pyrazole compounds of formula (I) and pharmaceutically acceptable salts thereof having CRTH2 (chemoattractant receptor-homologous molecule expressed on Th2 cells) receptor affecting activity, wherein W, L1 ,L2 , X,L3, Y, R1 and R2 are as defined in the specification and claims, to their use as medicaments and to pharmaceutical formulations, containing said compounds or containing a combination of said compounds with one or more active substances. Compounds of the disclosure include: { 3,5-Dimethyl-1-[4-(4-trifluoromethyl-benzenesulfinylmethyl)-benzyl]-1H-pyrazol-4-yl} -acetic acid, [3,5-Dimethyl-1-(4-phenylacetyl-benzyl)-1H-pyrazol-4-yl]-acetic acid and (1-{ 4-[1-(3,4-Dichloro-phenoxy)-ethyl]-benzyl} -3,5-dimethyl-1H-pyrazol-4-yl)-acetic acid. The compounds and compositions of the disclosure may be used for the prevention and/or treatment of inflammatory, infectious and immunoregulatory disorders, respiratory or gastrointestinal diseases or complaints, inflammatory diseases of the joints and allergic diseases of the nasopharynx, eyes, and skin.
