compound, pharmaceutical composition, methods for inhibiting the activity of a map p38 kinase enzyme, for treating or preventing autoimmune or inflammatory disease in an individual, and for treating, ameliorating or reducing the incidence of proliferative cell disease in an individual, use of compound and acid

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专利权人:

CHROMA THERAPEUTICS LTD

发明人:

David Festus Charles Moffat,Stephen John Davies,Stéphane Pintat

申请号：

BR112015008167

公开号：

BR112015008167A2

申请日:

2013.10.15

申请国别(地区):

BR

年份:

2017

代理人:

摘要：

1/1 summary “compound, pharmaceutical composition, methods for inhibiting the activity of a map p38 enzyme kinase, for the treatment or prevention of autoimmune or inflammatory disease in an individual And for the treatment, amelioration or reduction of the incidence of proliferative cell disease in an individual, use of compost, and acidic the present invention. provides a compound which is: n- [2- {4- [6-amino-5- (2,4-difluorobenzoyl) -2-oxopyridin-1 (2h) -yl] -3,5-difluorophenyl} ethyl) tert-butyl 1-alaninate or a salt, hydrate or solvate thereof. The present invention also provides a pharmaceutical composition comprising the compound together with one or more pharmaceutically acceptable excipients and / or vehicles. the compound and composition are useful for inhibiting the activity of a map p38 kinase enzyme. as such they may be used in the treatment of an autoimmune or inflammatory disease, or a proliferative cell disease. In addition, the invention provides an acid produced by hydrolysis of the ester group of the compound of the invention. the acid is n- [2- {4- [6-amino-5- (2,4-difluorobenzoyl) -2-oxopyridin-1 (2h) -yl] -3,5-difluorophenyl} ethyl) - l-alanine.1 / 1 resumo “composto, composiã‡ãƒo farmacãšutica, mã‰todos para a inibiã‡ãƒo da atividade de uma enzima quinase map p38, para o tratamento ou a prevenã‡ãƒo de doenã‡a autoimune ou inflamatã“ria em um indivã�duo, e para o tratamento, a melhoria ou a reduã‡ãƒo da incidãšncia de doenã‡a proliferativa de cã‰lulas em um indivã�duo, uso de composto, e, ã�cidoâ€� a presente invenã§ã£o fornece um composto que ã©: n-[2-{4-[6- amino-5-(2,4-difluorobenzoil)-2-oxopiridin-1(2h)-il]-3,5-difluorofenil}etil)- l-alaninato de terc-butila ou um seu sal, hidrato ou solvato. a presente invenã§ã£o tambã©m fornece uma composiã§ã£o farmacãªutica compreendendo o composto junto com um ou mais excipientes e/ou veã­culos farmaceuticamente aceitã¡veis. o composto e a composiã§ã£o sã£o ãºteis para a inibiã§ã£o da atividade de um

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