CURRY, JAYNE ELIZABETH,LYONS, JOHN FRANCIS,SQUIRES, MATTHEW SIMON,THOMPSON, NEIL THOMAS,THOMPSON, KYLA MERRIOM,WYATT, PAUL GRAHAM
申请号：
CA2594474
公开号：
CA2594474C
申请日:
2006.01.20
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The invention provides a combination of a cytotoxic compound or signallinginhibitor and a compound having the formula (0): or salts or tautomers or N-oxides or solvates thereof； wherein X is a group R1-A-NR4- or a 5- or 6-membered carbocyclic or heterocyclic ring； A is a bond, SO2, C=O, NRg(C=O) or0(C=O) wherein Rg is hydrogen or C1-4 hydrocarbyl optionally substituted byhydroxy or C1-4alkoxy； Y is a bond or an alkylene chain of 1, 2 or 3 carbonatoms in length； R1 is hydrogen； a carbocyclic or heterocyclic group havingfrom 3 to 12 ring members； or a C1-8hydrocarbyl group optionally substitutedby one or more substituents selected from halogen (e.g. fluorine), hydroxy, C1-4 hydrocarbyloxy, amino, mono- or di-C1-4 hydrocarbylamino, and carbocyclic orheterocyclic groups having from 3 to 12 ring members, and wherein 1 or 2 ofthe carbon atoms of the hydrocarbyl group may optionally be replaced by anatom or group selected from O, S, NH, SO, SO2； R2 is hydrogen； halogen； C1-4alkoxy (e.g. methoxy)； or a C1-4 hydrocarbyl group optionally substituted byhalogen (e.g. fluorine), hydroxyl or C1-4alkoxy (e.g. methoxy)； R3 is selectedfrom hydrogen and carbocyclic and heterocyclic groups having from 3 to 12 ringmembers； and R4 is hydrogen or a C1-4 hydrocarbyl group optionally substitutedby halogen (e.g. fluorine), hydroxyl or C1-4 alkoxy (e.g. methoxy).
